Source of dietary fibre and diverticular disease incidence: a prospective study of UK women. Issue 9 (2nd January 2014)

• Record Type: Journal Article
• Authors: Crowe, Francesca L; Balkwill, Angela; Cairns, Benjamin J; Appleby, Paul N; Green, Jane; Reeves, Gillian K; Key, Timothy J; Beral, Valerie
• Other Names: Abbott Simon author non-byline.; Armstrong Miranda author non-byline.; Benson Vicky author non-byline.; Black Judith author non-byline.; Brown Anna author non-byline.; Bull Diana author non-byline.; Callaghan Kathy author non-byline.; Canoy Dexter author non-byline.; Chadwick Andrew author non-byline.; Chivenga James author non-byline.; Crossley Barbara author non-byline.; Ewart Dave author non-byline.; Ewart Sarah author non-byline.; Fletcher Lee author non-byline.; Floud Sarah author non-byline.; Gathani Toral author non-byline.; Gerrard Laura author non-byline.; Goodill Adrian author non-byline.; Guiver Lynden author non-byline.; Kan Sau Wan author non-byline.; Kirichek Oksana author non-byline.; Keene Carol author non-byline.; Kroll Mary author non-byline.; Langston Nicky author non-byline.; Lingard Isobel author non-byline.; Lowe Pauline author non-byline.; Luque Maria Jose author non-byline.; Moser Kath author non-byline.; Pank Lynn author non-byline.; Pirie Kirstin author non-byline.; Sherman Emma author non-byline.; Sherry-Starmer Evie author non-byline.; Schmidt Julie author non-byline.; Simmonds Moya author non-byline.; Strange Helena author non-byline.; Sweetland Sian author non-byline.; Timadjer Alison author non-byline.; Tipper Sarah author non-byline.; Travis Ruth author non-byline.; Trickett Lyndsey author non-byline.; Wright Lucy author non-byline.; Yang Owen author non-byline.; Young Heather author non-byline.;
• Is Part Of: Gut. Volume 63:Issue 9(2014)
• Page Start: 1450
• Page End: 1456
• Publication Date: 2014-01-02
• Subjects: diet -- dietary fibre -- diverticular disease -- prospective; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gutjnl-2013-304644
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Background: Previous prospective studies have found the incidence of intestinal diverticular disease decreased with increasing intakes of dietary fibre, but associations by the fibre source are less well characterised. We assessed these associations in a large UK prospective study of middle-aged women. Methods and findings: During 6 (SD 1) years follow-up of 690 075 women without known diverticular disease who had not changed their diet in the last 5 years, 17 325 were admitted to hospital or died with diverticular disease. Dietary fibre intake was assessed using a validated 40-item food questionnaire and remeasured 1 year later in 4265 randomly-selected women. Mean total dietary fibre intake at baseline was 13.8 (SD 5.0) g/day, of which 42% came from cereals, 22% from fruits, 19% from vegetables (not potatoes) and 15% from potatoes. The relative risk (95% CI) for diverticular disease per 5 g/day fibre intake was 0.86 (0.84 to 0.88). There was significant heterogeneity by the four main sources of fibre (p<0.0001), with relative risks, adjusted for each of the other sources of dietary fibre of 0.84 (0.81 to 0.88) per 5 g/day for cereal, 0.81 (0.77 to 0.86) per 5 g/day for fruit, 1.03 (0.93 to 1.14) per 5 g/day for vegetable and 1.04 (1.02 to 1.07) per 1 g/day for potato fibre. Conclusions: A higher intake of dietary fibre is associated with a reduced risk of diverticular disease. The associations with diverticular disease appear to vary by fibre source, and the reasons for this variation are unclear.