Use of three-dimensional printing of a lumbar skeletal model for intrathecal administration of nusinersen: a brief technical report. Issue 10 (18th August 2020)

• Record Type: Journal Article
• Authors: Abe, Hiroaki; Inoue, Reo; Tsuchida, Rikuhei; Azuma, Kenji; Ino, Kenji; Konishi, Mitsuru; Hozumi, Jun; Sumitani, Masahiko
• Is Part Of: Regional anesthesia and pain medicine. Volume 45:Issue 10(2020)
• Page Start: 757
• Page End: 760
• Publication Date: 2020-08-18
• Subjects: diagnostic techniques and procedures -- injections, spinal -- multimodal imaging; Conduction anesthesia -- Periodicals; Pain medicine -- Periodicals; 617.964
• DOI: 10.1136/rapm-2020-101607
• Languages: English
• ISSNs: 1098-7339

Abstract

Abstract : Spinal muscular atrophy (SMA) is an autosomal recessive hereditary neurodegenerative disease causing progressive muscle atrophy, weakness and kyphoscoliosis. Nusinersen is a therapeutic agent for SMA that should be administered intrathecally. However, due to severe kyphoscoliosis, lumbar puncture can be challenging. Here, we present our experience of intrathecal administration of nusinersen in an SMA patient with severe kyphoscoliosis using a life-size three-dimensional printing (3D) skeletal model created with 3D printer. With this strategy, we were able to rapidly and safely perform the lumbar puncture.