Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis. (February 2021)

• Record Type: Journal Article
• Authors: Musillo, Chiara; Borgi, Marta; Saul, Nadine; Möller, Steffen; Luyten, Walter; Berry, Alessandra; Cirulli, Francesca
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 121(2021)
• Page Start: 89
• Page End: 105
• Publication Date: 2021-02
• Subjects: 5-HT 5-hydroxytryptamine or serotonin -- Ach Acetylcholine -- AChE Acetylcholinesterase -- BDNF Brain-Derived Neurotrophic Factor -- BrdU Bromodeoxyuridine -- CaMKII-α Calcium/calmodulin-dependent protein kinase II subunit α -- CAT Catalase -- ChAT Choline acetyltransferase -- CREB cyclic adenosine monophosphate-responsive element-binding -- CSD Contextual serial discrimination -- DA Dopamine -- DCX Doublecortin -- DG Dentate Gyrus -- GAP-43 Growth-Associated Protein-43 -- GR Glutathione Reductase -- GSH-Px or GPx Glutathione Peroxidase -- HO-1 Heme Oxygenase 1 -- HPA Hypothalamic-Pituitary-Adrenal -- i.p. intraperitoneal -- LHP Lipid Hydroperoxides -- MDA Malondialdehyde -- mTOR mammalian Target of Rapamycin -- MWM Morris Water Maze -- n.s. not specified -- NA Noradrenaline -- NE Norepinephrine -- NGF Nerve Growth Factor -- NRF2 Nuclear Factor Erythroid 2-Related Factor 2 -- OBDT Operant Brightness Discrimination Task -- PA Passive Avoidance -- pCREB phosphorylated Cyclic Adenosine Monophosphate-Responsive Element-Binding -- pPKA phosphorylated Protein Kinase A -- PSD95 Postsynaptic Density Protein 95 -- PWM Passageway Water Maze -- RAM Radial Arm Maze -- ROS Reactive Oxygen Species -- SNAP 25 Synaptosomal-Associated Protein 25 -- SOD Superoxide Dismutase -- SYP Synaptophysin -- TBARS Thiobarbituric acid-reactive substances -- VAChT Vesicular Acetylcholine Transporter -- w/w weight/weight; Mice -- Rats -- Animal model -- Ageing -- Memory -- Dietary supplements -- Metabolism -- Physiological stress -- Locomotion -- Healthy ageing; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2020.12.001
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: Natural products promote healthspan in rodent models of physiological ageing. Oxidative stress is a target of natural products. Both brain and peripheral tissues benefit from treatment with natural products. Positive effects of natural products are observed on cognition as well as on physical performance. Abstract: Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of years spent in good health; "healthspan" is indeed the emerging concept of such quest for ageing without chronic or disabling diseases and dysfunctions. Regular consumption of natural products might improve healthspan, although the mechanisms of action are still poorly understood. Since preclinical studies aimed to assess the efficacy and safety of these compounds are growing, we performed a systematic review and meta-analysis on the effects of natural products on healthspan in mouse and rat models of physiological ageing. Results indicate that natural compounds show robust effects improving stress resistance and cognitive abilities. These promising data call for further studies investigating the underlying mechanisms in more depth.