Dynamics of T-cell IFN-γ and miR-29a expression during active pulmonary tuberculosis. (30th June 2014)

• Record Type: Journal Article
• Authors: Afum-Adjei Awuah, Anthony; Ueberberg, Bianca; Owusu-Dabo, Ellis; Frempong, Margaret; Jacobsen, Marc
• Is Part Of: International immunology. Volume 26:Number 10(2014:Oct.)
• Page Start: 579
• Page End: 582
• Publication Date: 2014-06-30
• Subjects: IFN-γ -- miR-29a -- TB -- T cell; Immunology -- Periodicals; 616.079
• DOI: 10.1093/intimm/dxu068
• Languages: English
• ISSNs: 0953-8178

Abstract

Abstract : Levels of IFNγ and miR-29a during treatment for active tuberculosis Abstract: IFN-γ is crucial for protection against Mycobacterium tuberculosis . miR-29 was recently shown to non-redundantly inhibit IFN-γ. Here, we investigated IFN-γ and miR-29a expression dynamics of CD4 + T cells from patients during active tuberculosis (TB) ( n = 32) and in household contacts who were latently M. tuberculosis infected ( n = 19) from Ghana. Whereas M. tuberculosis -specific IFN-γ expression was similar during TB chemotherapy, superantigen stimulation indicated generally impaired IFN-γ expression in TB patients. No interdependency between miR-29a and IFN-γ expression of T cells was observed. However, miR-29a was differentially expressed in T cells during chemotherapy. We concluded that differential miR-29a expression in active TB was not causative for impaired IFN-γ expression.