Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics. Issue 16 (1st September 2018)

• Record Type: Journal Article
• Authors: Makhaeva, Galina F.; Boltneva, Natalia P.; Lushchekina, Sofya V.; Rudakova, Elena V.; Serebryakova, Olga G.; Kulikova, Larisa N.; Beloglazkin, Andrei A.; Borisov, Roman S.; Richardson, Rudy J.
• Is Part Of: Bioorganic & medicinal chemistry. Volume 26:Issue 16(2018)
• Page Start: 4716
• Page End: 4725
• Publication Date: 2018-09-01
• Subjects: 2-vinyl-substituted chromones -- Chromenopyridine -- Tandem transformation, Activated alkynes -- Esterase profile -- Butyrylcholinesterase inhibitors -- Molecular docking -- Alzheimer's disease; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2018.08.010
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Highlights: A series of substituted chromeno[3, 2- c ]pyridines was synthesized. Some 2-vinyl-substituted chromones were selective BChE inhibitors. Molecular docking explained the inhibitory properties of the compounds. Abstract: We investigated the biological activity of a series of substituted chromeno[3, 2- c ]pyridines, including compounds previously synthesized by our group and novel compounds whose syntheses are reported here. Tandem transformation of their tetrahydropyridine ring under the action of activated alkynes yielding 2-vinylsubstituted chromones was used to prepare nitrogen-containing derivatives of a biologically active chromone system. The inhibitory activity of these chromone derivatives against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and carboxylesterase (CaE) was investigated using the methods of enzyme kinetics and molecular docking. Antioxidant (antiradical) activity of the compounds was assessed in the ABTS assay. The results demonstrated that a subset of the studied chromone derivatives selectively inhibit BChE but do not exhibit antiradical activity. In addition, the results of molecular docking effectively explained the observed features in the efficacy, selectivity, and mechanism of BChE inhibition by the chromone derivatives.