A unidirectional porous beta-tricalcium phosphate material (Affinos®) for reconstruction of bony defects after excision of fibular bone for spinal surgery graft. (August 2019)

• Record Type: Journal Article
• Authors: Noguchi, Hiroshi; Funayama, Toru; Koda, Masao; Iijima, Yasushi; Kumagai, Hiroshi; Ishikawa, Tetsuhiro; Aiba, Atsuomi; Abe, Tetsuya; Nagashima, Katsuya; Miura, Kousei; Izawa, Shigeo; Maki, Satoshi; Furuya, Takeo; Yamazaki, Masashi
• Is Part Of: Journal of clinical neuroscience. Volume 66(2019)
• Page Start: 71
• Page End: 76
• Publication Date: 2019-08
• Subjects: β-tricalcium phosphate -- Bone graft donor site -- Bone remodeling -- Regeneration of fibula -- Spinal fusion surgery; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2019.05.021
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Bone regeneration induced by Affinos® or OSferion® in fibula defects was compared. Implanted β-TCP can promote repair of bone defects to regenerate fibula bone. Fibula continuity for the Affinos® and OSferion® groups did not differ significantly. Affinos® was absorbed more slowly than OSferion® . The fibula defect filling ratio was higher for Affinos® than for OSferion® . Abstract: The aim of this study was to elucidate the bone regeneration-inducing capability of Affinos®, a newly developed, high-porosity unidirectional porous β-TCP artificial bone. We compared the ability of Affinos® and OSferion®, a commercially available β-TCP product, to induce bone regeneration following implantation into bony defects left after fibula harvesting for spinal fusion surgery. Study subjects underwent surgery to harvest non-vascularized fibula grafts for spinal fusion surgery and were implanted with either Affinos® (19 patients) or OSferion® (15 patients, control group) at the defect site. The minimal and mean follow up periods were 6 and 11 months after surgery, respectively. X-rays of the lower leg taken 1–2 weeks after surgery and at the final follow-up visit were used to evaluate fibular-β-TCP continuity and fibula defect filling ratio. There was no significant difference in radiographic continuity in the fibula between the two groups. The fibula defect filling ratio for the Affinos® group decreased from 0.94 ± 0.17 at 1–2 weeks to 0.77 ± 0.14 at 10 months. For the OSferion® control group, the fibula defect filling ratio decreased from 0.94 ± 0.14 at 1–2 weeks to 0.52 ± 0.27 at final follow-up. The Affinos® group showed a significantly higher fibula defect filling ratio compared to that for the OSferion® group (p = 0.003). These results indicate that Affinos® has slow absorption rates and significant defect filling activity compared with OSferion®. Thus, Affinos® could be a suitable substitute to fill bony defects induced by fibula harvesting for spinal reconstruction surgery.