Megalin: A bridge connecting kidney, the renin-angiotensin system, and atherosclerosis. (January 2020)

• Record Type: Journal Article
• Authors: Kukida, Masayoshi; Sawada, Hisashi; Daugherty, Alan; Lu, Hong S.
• Is Part Of: Pharmacological research. Volume 151(2020)
• Publication Date: 2020-01
• Subjects: Megalin -- Kidney -- Renin angiotensin system -- Atherosclerosis; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2019.104537
• Languages: English
• ISSNs: 1043-6618

Abstract

Abstract: Megalin is a member of the low-density lipoprotein receptor superfamily. It has been recognized as an endocytic receptor for a large spectrum of ligands. As a consequence, megalin regulates homeostasis of many molecules and affects multiple physiological and pathophysiological functions. The renin-angiotensin system is a hormonal system. A number of studies have reported contributions of the renin-angiotensin system to atherosclerosis. There is evolving evidence that megalin is a regulator of the renin-angiotensin system, and contributes to atherosclerosis. This brief review provides contemporary insights into effects of megalin on renal functions, the renin-angiotensin system, and atherosclerosis.