Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii. Issue 12 (1st July 2018)

• Record Type: Journal Article
• Authors: Nakamura, Fumiaki; Maejima, Hiroshi; Kawamura, Midori; Arai, Daisuke; Okino, Tatsufumi; Zhao, Meng; Ye, Tao; Lee, Jungyeol; Chang, Young-Tae; Fusetani, Nobuhiro; Nakao, Yoichi
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 28:Issue 12(2018)
• Page Start: 2206
• Page End: 2209
• Publication Date: 2018-07-01
• Subjects: Pentapeptide -- Cyanobacterium -- Astrocyte differentiation -- Neural stem cells -- Marine natural products; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2018.04.067
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Highlights: A new cyclic pentapeptide isolated from the marine cyanobacterium. Moderately cytotoxic against HeLa cells. Induced differentiation of neural stem cells into astrocytes. Abstract: Kakeromamide A (1 ), a new cyclic pentapeptide encompassing a thiazole ring moiety and a β -amino acid, was isolated from the marine cyanobacterium Moorea bouillonii . Its structure was elucidated by the spectral analysis and the modified Marfey's method. Compound 1 induced differentiation of neural stem cells into astrocytes at the concentration of 10 µM.