Recent advances of magneto-thermal capabilities of nanoparticles: From design principles to biomedical applications. (April 2017)

• Record Type: Journal Article
• Authors: Noh, Seung-hyun; Moon, Seung Ho; Shin, Tae-Hyun; Lim, Yongjun; Cheon, Jinwoo
• Is Part Of: Nano today. Volume 13(2017)
• Page Start: 61
• Page End: 76
• Publication Date: 2017-04
• Subjects: Nanotechnology -- Periodicals; Nanosciences -- Périodiques; 620.505
• DOI: 10.1016/j.nantod.2017.02.006
• Languages: English
• ISSNs: 1748-0132

Abstract

Graphical abstract: Highlights: Basic principles of heat dissipation of magnetic nanoparticles. Nanoparticle design considerations for tuning the magnetism that governs magnetic heating efficiency, such as specific loss power ( SLP ). Emerging approaches for the use of heat-generating nanoparticles for dual-mode magnetic hyperthermia, magnetothermally triggered drug delivery, and the magnetothermal control of cellular activities. Abstract: Magnetic nanoparticle (MNP)-mediated heating systems have emerged as an effective strategy for the fine control of biological systems from hyperthermia to cell signaling in a spatiotemporally controlled fashion. To achieve satisfactory performance, advanced design concepts have been developed to tailor the magnetism that directly affects the heating properties of nanoparticles. In this review, we focus on recent advances in magnetism-engineered nanoparticles. Fundamental principles of magnetic heating mechanisms and related key magnetic parameters are discussed first to provide instructive guidelines for the design of MNPs with enhanced heating efficiency. Then, we highlight recent progress in MNPs for optimized heat generation with unique design approaches to control magnetism. Finally, we discuss highly effective biomedical application studies such as dual-mode magnetic hyperthermia, magnetothermally triggered drug delivery, and the magnetothermal control of cellular activities.