Isosteric ribavirin analogues: Synthesis and antiviral activities. Issue 1 (1st January 2018)

• Record Type: Journal Article
• Authors: Zhurilo, Nikolay I.; Chudinov, Mikhail V.; Matveev, Andrey V.; Smirnova, Olga S.; Konstantinova, Irina D.; Miroshnikov, Anatoly I.; Prutkov, Alexander N.; Grebenkina, Lyubov E.; Pulkova, Natalya V.; Shvets, Vitaly I.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 28:Issue 1(2018)
• Page Start: 11
• Page End: 14
• Publication Date: 2018-01-01
• Subjects: Ribavirin -- Isosterism -- Nucleoside analogues -- Antivirals; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2017.11.029
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant antiviral action against hepatitis C virus (HCV), herpes simplex (HCV-1) and influenza A virus comparable to that of ribavirin itself. The data obtained confirm the proposed theory of the ribavirin possible antiviral activity mechanism related with bioisosterism.