Structural brain correlates of interpersonal violence: Systematic review and voxel-based meta-analysis of neuroimaging studies. (30th September 2017)

• Record Type: Journal Article
• Authors: Lamsma, Jelle; Mackay, Clare; Fazel, Seena
• Is Part Of: Psychiatry research. Volume 267(2017)
• Page Start: 69
• Page End: 73
• Publication Date: 2017-09-30
• Subjects: Violence Grey matter volume MRI Prefrontal cortex Amygdala; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2017.07.006
• Languages: English
• ISSNs: 0925-4927

Abstract

Abstract: Owing to inconsistent nomenclature and results, we have undertaken a label-based review and anatomical likelihood estimation (ALE) meta-analysis of studies measuring the quantitative association between regional grey matter (GM) volume and interpersonal violence. Following PRISMA guidelines, we identified studies by searching 3 online databases (Embase, Medline, PsycInfo) and reference lists. Thirty-five studies were included in the label-based review, providing information for 1288 participants and 86 brain regions. Per region, 0–57% of the results indicated significant reductions in GM volume, while 0–23% indicated significant increases. The only region for which more than half of all results indicated significant reductions was the parietal lobe. However, these results were dispersed across subregions. The ALE meta-analysis, which included 6 whole-brain voxel-based morphometry studies totaling 278 participants and reporting 144 foci, showed no significant clusters of reduced GM volume. No material differences were observed when excluding experiments using reactive violence as outcome or subjects diagnosed with psychopathy. Possible explanations for these findings are phenomenological and etiological heterogeneity, and insufficient power in the label-based review and ALE meta-analysis to detect small effects. We recommend that future studies distinguish between subtypes of interpersonal violence, and investigate mediation by underlying emotional and cognitive processes. Highlights: We conducted a label-based review of 86 brain regions from 35 neuroimaging studies. In addition, we report a voxel-based meta-analysis of 144 foci from 6 studies. Regional grey matter volume was not consistently associated with violent outcomes. Future research should account for subtypes and situational aspects of violence.