Motor sequence learning in patients with ideomotor apraxia: Effects of long-term training. (20th August 2021)

• Record Type: Journal Article
• Authors: Willms, Sarah; Abel, Miriam; Karni, Avi; Gal, Carmit; Doyon, Julien; King, Bradley R.; Classen, Joseph; Rumpf, Jost-Julian; Buccino, Giovanni; Pellicano, Antonello; Klann, Juliane; Binkofski, Ferdinand
• Is Part Of: Neuropsychologia. Volume 159(2021)
• Publication Date: 2021-08-20
• Subjects: Apraxia -- chronic stroke -- motor sequence learning -- long term training -- motor memory; Neuropsychology -- Periodicals; Neurology -- Periodicals; Psychophysiology -- Periodicals; Neuropsychologie -- Périodiques; Neuropsychology; Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.neuropsychologia.2021.107921
• Languages: English
• ISSNs: 0028-3932

Abstract

Abstract: Recent studies show that limb apraxia is a quite frequent, yet often underdiagnosed, higher motor impairment following stroke. Because it adversely affects every-day life and personal independence, successful rehabilitation of apraxia is essential for personal well-being. Nevertheless, evidence of long-term efficacy of training schemes and generalization to untrained actions is still scarce. One possible reason for the tendency of this neurological disorder to persist may be a deficit in planning, conceptualisation and storage of complex motor acts. This pilot study aims at investigating explicit motor learning in apractic stroke patients. In particular, we addressed the ability of apractic patients to learn and to retain new explicit sequential finger movements across 10 training sessions over a 3-week interval. Nine stroke patients with ideomotor apraxia in its chronic stage participated in a multi-session training regimen and were included in data analyses. Patients performed an explicit finger sequence learning task (MSLT – motor sequence learning task), which is a well-established paradigm to investigate motor learning and memory processes. Patients improved task performance in terms of speed and accuracy across sessions. Specifically, they showed a noticeable reduction in the mean time needed to perform a correct sequence and the number of erroneous sequences. We found also a trend for improved performance at the Goldenberg apraxia test protocol: "imitation of meaningless hand and finger gestures" relative to when assessed before the MSLT training. Patients with ideomotor apraxia demonstrated the ability to acquire and maintain a novel sequence of movements; and, this training was associated with hints towards improvement of apraxia symptoms. Highlights: Apraxia patients with deficits of imitation and pantomime can learn new explicit motor sequences in a multi-session training. A trend was observed for the improvement of apraxia symptoms following motor sequence learning task (MSLT) training. Intensive motor training promisses to be effective in Apraxia.