THU0395 Adult Onset Still's Disease: A Multicenter Retrospective Cohort Study of 233 Italian Patients. (10th June 2014)

• Record Type: Journal Article
• Authors: Sfriso, P.; Priori, R.; Colafrancesco, S.; Valesini, G.; Rossi, S.; Montecucco, C.; D'Ascanio, A.; Carli, L.; Bombardieri, S.; La Selva, G.; Iannone, F.; Lapadula, G.; Alivernini, S.; Ferraccioli, G.; Caso, F.; Colaci, M.; Ferri, C.; Iacono, D.; La Montagna, G.; Costa, L.; Scarpa, R.; Lo Monaco, A.; Bagnari, V.; Govoni, M.; Piazza, I.; Adami, S.; Schinocca, C.; Ciccia, F.; Triolo, G.; Alessandri, E.; Cutolo, M.; Cantarini, L.; Galeazzi, M.; Punzi, L.;
• Is Part Of: Annals of the rheumatic diseases. Volume 73:Supplement 2(2014)
• Page Start: 318
• Page End: 318
• Publication Date: 2014-06-10
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2014-eular.5300
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Adult onset Still's disease (AOSD) is a rare rheumatic disease with an estimated prevalence of less than 1 case per 100, 000 population. The diagnosis is difficult and is often delayed due to the lack of specific diagnostic tests and the need to rule out other pathological entities. Objectives: To describe the clinical characteristics of a multicenter Italian case series of patients with AOSD. Methods: 14 Italian University Hospital centers participated in the study. A standardized medical record containing clinical data, laboratory investigations, disease patterns and the different therapies has been sent to all participating centers. Each center collected data retrospectively. Results: In the first wave of data collection, from March to May 2013, 233 patients were included with AOSD according to Yamaguchi criteria (125 males, 53.6%, mean age at onset: 40.2±16.2 years, time between onset and diagnosis: 242±650 days). The most frequent manifestations at onset were: arthralgia (93.0%), fever (92.6%), leukocytosis (89.0%), typical rash (67.7%), sore throat (61.8%), lymphadenopathy/splenomegaly (60.4%), increased liver enzymes (53.5%). In 56.4% of patients ferritin was increased more than 5 times the normal threshold. Fever intensity was recorded up to 41 ° C (mean 39.1±0.7), with a single daily peak in 27.3% of cases and 2 peaks in 51.9% of cases. The average duration of febrile episodes was 10.3 days with variable interval between episodes (average 3.2 days). Based on clinical evolution the disease was classified polycyclic systemic in 40.8%, chronic articular polycyclicin 30.7%, systemic monocyclic in 23.9% and chronic articular monocyclic in 4.6%. In 21.9% of cases, corticosteroids and traditional DMARDs have not been able to control the disease while biological drugs have been shown to be effective. 56 cycles of biological drugs were used in 51 patients: anakinra in 22 cases, etanercept in 15 cases, infliximab in 8 cases, adalimumab in 7 cases, rituximab in 3 cases, tocilizumab in 2 cases, abatacept and golimumab in 1 case each (anti- TNFalpha 52.5%, 37.3% anakinra, other 10.2%). Conclusions: This study presents the largest Italian multicentre series of AOSD patients. The main clinical and laboratory characteristics are in line with those reported in the literature. In more than 20% of patients biologics are the only drugs that allow to control the disease. Disclosure of Interest: : None declared DOI: 10.1136/annrheumdis-2014-eular.5300