Biomanufacturing of customized modular scaffolds for critical bone defects. Issue 1 (2019)

• Record Type: Journal Article
• Authors: Koc, Bahattin; Acar, Anil A.; Weightman, Andrew; Cooper, Glen; Blunn, Gordon; Bartolo, Paulo
• Is Part Of: CIRP annals. Volume 68:Issue 1(2019)
• Page Start: 209
• Page End: 212
• Publication Date: 2019
• Subjects: Additive manufacturing -- Biologically inspired design -- Biomanufacturing; Production engineering -- Research -- Periodicals; 670.5
• DOI: 10.1016/j.cirp.2019.04.106
• Languages: English
• ISSNs: 0007-8506

Abstract

Abstract: There is a significant unmet clinical need for modular and customized porous biodegradable constructs (scaffolds) for non-union large bone loss injuries. This paper proposes modelling and biomanufacturing of modular and customizable porous constructs for patient-specific critical bone defects. A computational geometry-based algorithm was developed to model modular porous constructs using a parametric femur model based on the frequency of common injuries. The generated modular constructs are used to generate biomimetic path planning for three-dimensional (3D) printing of modular scaffold pieces. The developed method can be used for regenerating bone tissue for treating non-union large bone defects.