Janus nanoparticles: New generation of multifunctional nanocarriers in drug delivery, bioimaging and theranostics. (March 2020)

• Record Type: Journal Article
• Authors: Rahiminezhad, Zahra; Tamaddon, Ali Mohammad; Borandeh, Sedigheh; Abolmaali, Samira Sadat
• Is Part Of: Applied materials today. Volume 18(2020)
• Publication Date: 2020-03
• Subjects: JNPS Janus nanoparticles -- DOX doxorubicin -- 6-MP 6-mercaptopurine -- EHD co-jetting electro-hydrodynamic jetting -- PAA poly(acrylic acid) -- PVP poly(vinyl pyrrolidone) -- PSSNa polystyrene sodium sulfonate -- PDMAEMA polydimethylamino ethylmethacrylate -- 4-MBA 4-mercaptobenzoic acid -- THF Tetrahydrofuran -- pNIPAM Poly(N-isopropylacrylamide) -- SiNPs silica nanoparticles -- scCO2 supercritical carbon dioxide -- PS polystyrene microspheres -- FNPS fluidic nanoprecipitation system -- IPN interpenetrating polymer network -- PEO poly(ethylene oxide) -- p(AAm- co –AA) poly(acrylamide-co-acrylic acid) -- PLG poly(lactic-co-glycolic acid) -- cPS carboxylated polystyrene particles -- PVA poly(vinyl alcohol) -- 2PDMAEMA 2-(dimethylamino)ethyl methacrylate -- DPP distillation precipitation polymerization -- EGDMA ethylene glycol dimethacrylate -- RAFT reversible addition fragmentation chain transfer -- PtBMA poly(tertbutylmethacrylate) -- PCEMA poly(2-(cinnamoyloxy) ethyl methacrylate) -- ATRP atom transfer radical polymerization -- SMPs Shape-memory polymers -- SMJNPs shape memory of Janus nanoparticles -- SU-PCL sucrose-poly(e-caprolactone) -- BP benzophenone -- ROP ring-opening polymerization -- cis-DDP cis-Dichlorodiamineplatinum(II) -- DDS drug delivery system -- UCNP upconversion nanoparticle -- mSiO2 mesoporous silica -- PMO periodic mesoporous organosilica -- Azo azobenzene -- NIR near infrared -- UV/Vis ultraviolet/visible -- PTT Photothermal therapy -- M-mSiO2 nano-bullets magnetic Fe3O4 silica nano-bullets -- Fe3O4-mSiO2 JNPs magnetic mesoporous silica Janus nanoparticles -- FRET fluorescence resonance energy transfer -- SERS surface-enhanced Raman scattering -- CMR 7-hydroxycoumarin-3-carboxylate -- GSH glutathione -- UFO- like JNPs unidentified flying object-like Janus nanoparticles -- PdNS palladium nanosheet -- ZIF-8 Zeolitic imidazolate framework-8 -- CD cyclodextrin -- HCPT 10-hydroxycamptothecin -- OJNPs octopus-type JNPs -- LA lactobionic acid -- FA folic acid -- CTI computed tomography imaging -- MRI magnetic resonance imaging -- PEG-SH poly (ethylene glycol) thiol -- LSPR localized surface plasmon resonance -- PCL poly(3-caprolactone) -- AuNC gold nanocage -- GNRs-mSiO2 Gold nanorods- mesoporous silica -- MSOT multispectral photoacoustic tomography -- JVs Janus vesicles -- MNPs magnetic NPs -- BCP block copolymer -- AuNPs gold nanoparticles -- PA photoacoustic imaging -- DSPE-PEG-COOH 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-carboxy-polyethyleneglycol -- Cy5 Cyanine5 -- EPR effect enhanced permeability and retention effect -- cRGD cyclic RGD peptide -- OI optical imaging -- Ach acetylcholine -- Ru(bpy)3] Cl2 Tris(2, 2-bipyridyl) ruthenium(II)chloride -- P-Et phenyleneethylene -- Cr chromium -- Pt platinum -- PC phosphatidylcholine -- A-HMS ammoniated-hollow mesoporous silica -- VLPs Virus-like nanoparticles -- JVNs Janus Virus Nanomotors -- BMV Brome mosaic virus -- CCMV cowpea chlorotic mottle virus -- Tz tetrazine -- TCo trans-cyclooctene -- bMS big magnetic microsphere -- sMS small magnetic microsphere -- MALDI-TOF-MS matrix-assisted laser desorption ionization time-of-flight mass spectrometry -- CEA carcinoembryonic antigen -- Ag antigen -- pAb polyclonal antibody -- mAb monoclonal antibody -- RJPs retrore?ective Janus microparticles; Janus nanoparticles -- Drug delivery -- Theranostics -- Bioimaging -- Muitifunctional carrier; Materials science -- Periodicals; Materials -- Research -- Periodicals; 620.1105
• DOI: 10.1016/j.apmt.2019.100513
• Languages: English
• ISSNs: 2352-9407

Abstract

Graphical abstract: Highlights: Janus nanoparticles (JNPs) are colloidal dispersions with anisotropic nature. Masking, self-assembly, sputtering and microfluidics are used for JNPs synthesis. JNPs incorporates both hydrophobic and hydrophilic drugs simultaneously. JNPs are elaborately modified for molecular targeting and stimuli-responsiveness. JNPs are envisioned for theranostic applications in era of personalized medicine. Abstract: Janus nanoparticles (JNPs) are anisotropic particles composed of two distinct sides with differences in chemical nature and/or polarity on each side. These particles have attracted much attention in recent years due to their dual functionality, anisotropic nature and potential applications in material science and biomedicine such as nanocorals, micro/nanomotors, catalyst, and stabilizers. With the presence of different functional group and various chemical compounds on each side, JNPs can simultaneously be modified for specific needs in drug delivery, such as loading two drugs, grafting with a targeting ligand and imaging agents. Moreover, the site-selective modification of each face allows combining different agents within a single particle without significant interaction, leading to their versatile usage in theranostics. This review discusses the main strategies used for synthesizing JNPs with controllable morphology in a wide range of sizes and surface functionality by highlighting JNPs important properties and applications in the field of drug delivery with a focus on theranostics.