Early TCR Signaling Sweetens Effector Function through PDHK1. (September 2018)

• Record Type: Journal Article
• Authors: Weisshaar, Nina; Madi, Alaa; Cui, Guoliang
• Is Part Of: Trends in endocrinology and metabolism. Volume 29:Number 9(2018)
• Page Start: 595
• Page End: 597
• Publication Date: 2018-09
• Subjects: TCR signaling -- PDHK1 -- glycolysis -- T cell activation; Endocrinology -- Periodicals; Metabolism -- Periodicals; Metabolism; 616.4
• DOI: 10.1016/j.tem.2018.03.016
• Languages: English
• ISSNs: 1043-2760

Abstract

Abstract : T cells rapidly engage glycolysis upon activation. The signaling pathways through which T cell receptor (TCR) activation initiates glycolysis have been a mystery. A long-awaited answer has been provided by Menk et al ., who show that pyruvate dehydrogenase kinase 1 (PDHK1) is in the center of signaling events linking TCR activation to glycolysis.