Polyprenylated polycyclic acylphloroglucinol: Angiogenesis inhibitor from Garcinia multiflora. Issue 10 (1st June 2018)

• Record Type: Journal Article
• Authors: Cheng, Lin-Yang; Chen, Chun-Lin; Kuo, Yueh-Hsiung; Chang, Tsung-Hsien; Lin, I-Wei; Wang, Shih-Wei; Chung, Mei-Ing; Chen, Jih-Jung
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 28:Issue 10(2018)
• Page Start: 1860
• Page End: 1863
• Publication Date: 2018-06-01
• Subjects: Garcinia multiflora -- Guttiferae -- Polyprenylated polycyclic acylphloroglucinol -- Garcimultiflorone K -- Angiogenesis inhibitor; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2018.04.006
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Highlights: Three compounds (1 –3 ) were isolated from Garcinia multiflora . Compound 1 exhibited potent anti-angiogenic activity. Compound 1 exhibited growth-inhibition against SK-Hep-1 and PC-3 cells. Compound 1 is a potent angiogenesis inhibitor and anti-cancer agent. Abstract: A new polyprenylated polycyclic acylphloroglucinol, garcimultiflorone K (1 ), has been isolated from the stems of Garcinia multiflora, together with two known compounds, garcimultiflorone A (2 ) and garcimultiflorone B (3 ). The structure of new compound 1 was determined through spectroscopic methods including 1D and 2D NMR and MS analyses. The anti-angiogenic and anti-cancer effects of compounds 1 –3 were evaluated in human endothelial progenitor cells (EPCs) and cancer cells. Of these, garcimultiflorone K (1 ) displayed the most potent anti-angiogenic property by suppressing cell growth and tube formation of EPCs. Compound 1 also exhibited growth-inhibitory activities against human hepatocellular carcinoma cell line SK-Hep-1 and hormone refractory prostate cancer cell line PC-3 with GI50 values of 4.3 ± 1.6 and 6.6 ± 0.4 μM, respectively.