Moderating effect of PLIN4 genetic variant on impulsivity traits in 5-year-old-children born small for gestational age. (October 2018)

• Record Type: Journal Article
• Authors: Rodrigues, Danitsa Marcos; Manfro, Gisele Gus; Levitan, Robert Daniel; Steiner, Meir; Meaney, Michael Joseph; Silveira, Patrícia Pelufo
• Is Part Of: Prostaglandins, leukotrienes, and essential fatty acids. Volume 137(2018)
• Page Start: 19
• Page End: 25
• Publication Date: 2018-10
• Subjects: Small for gestational age -- Lipid droplet storage, -- Inhibitory control -- Impulsivity -- Single nucleotide polymorphism -- Omega-3 polyunsaturated fatty acids; Lipids -- Periodicals; Unsaturated fatty acids -- Periodicals; Prostaglandins -- Periodicals; Leukotrienes -- Periodicals; Fatty Acids, Unsaturated -- Periodicals; Acides gras insaturés -- Périodiques; Prostaglandines -- Périodiques; Leucotriènes -- Périodiques; Lipides -- Périodiques; 612.01577
• DOI: 10.1016/j.plefa.2018.07.013
• Languages: English
• ISSNs: 0952-3278

Abstract

Highlights: A allele of the rs8887 SNP ( PLIN4 gene) is associated with increased responsiveness to consumed n-3 PUFAs. We found an interaction between fetal growth and presence of the A allele on a inhibitory control task, demonstranting that lower birth weight is associated wtih poor inhibitory control only in the non-carriers individuals. Dietary n-3 PUFAs in infancy may protect small for gestional age children developing impulsive behaviors. Abstract: Poor fetal growth is associated with long-term behavioral, metabolic and psychiatric alterations, including impulsivity, insulin resistance, and mood disorders. However, the consumption of omega-3 polyunsaturated fatty acid (n-3 PUFA) seems to be protective for this population, improving inhibitory control and behavioral reactivity. We investigated whether the presence of the A allele of rs8887 SNP ( PLIN4 gene), known to be associated with increased sensitivity to the consumption of n-3 PUFAs, interacts with fetal growth influencing inhibitory control. 152 five-year-old children were genotyped and performed the Stop Signal Task (SSRT). There was a significant interaction between birth weight and the presence of the A allele on SSRT performance, in which lower birth weight associated with poorer inhibitory control only in non-carriers. These results suggest that a higher responsiveness to n-3 PUFAS protects small for gestational age children from developing poor response inhibition, highlighting that optimizing n-3 PUFA intake may benefit this population.