Repeated measures of prenatal thallium exposure and placental inflammatory cytokine mRNA expression: The Ma'anshan birth cohort (MABC) study. (May 2020)

• Record Type: Journal Article
• Authors: Zhu, Yuan-duo; Liang, Chun-mei; Hu, Ya-bin; Li, Zhi-juan; Wang, Su-fang; Xiang, Hai-yun; Huang, Kun; Yan, Shuang-qin; Zhu, Peng; Liu, Ping; Tao, Fang-biao
• Is Part Of: Chemosphere. Volume 246(2020)
• Publication Date: 2020-05
• Subjects: Thallium -- Placenta -- Inflammation -- Pregnant women -- Birth cohort -- Repeated measures analysis; pre-BMI pre-pregnancy body mass index -- CRP C-reactive protein -- TNF-α Tumor necrosis factor -- α IL-1β Interleukin -1β -- IL6 Interleukin −6 -- IL8 Interleukin −8 -- IL10 Interleukin −10 -- IL4 Interleukin −4 -- IFN-γ Interferon- γ -- MCP-1 Monocyte chemoattractant protein-1 -- NF-κB Nuclear factor kappa-light-chain-enhancer of activated B-cells; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2019.125721
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Thallium (Tl), a ubiquitous environmental toxicant, can cross the placental barrier during pregnancy. However, the effects of prenatal Tl exposure on placental function are currently unclear. Based on the Ma'anshan Birth Cohort study, we examined whether long-term prenatal Tl exposure was associated with placental inflammation. Tl concentrations were quantified in serum samples (n = 7050) from 2515 pregnancy during each trimester, placental inflammatory cytokine mRNA expression was assessed in 2519 placenta tissues. Geometric mean values of serum Tl concentrations were 63.57, 63.63 and 48.71 ng/L for the first, second and third trimesters, respectively. After adjustment for potential confounders, serum Tl concentration was positively associated with CD68 (β: 0.30; 95% CI: 0.05, 0.56) in the first trimester and TNF-α (β: 0.12; 95% CI: 0.01, 0.23), IL-6 (β: 0.15; 95% CI: 0.05, 0.25) and CD68 (β: 0.25; 95% CI: 0.10, 0.39) in the third trimester, however was negatively associated with IL-4 (β: −0.21; 95% CI: −0.41, −0.01) and CD206 (β: −0.23; 95% CI: −0.45, −0.02) in the first trimester. Repeated measures analysis showed that TNF-α, IL-6 and CD68 increased by 0.11 (95% CI: 0.01, 0.21), 0.12 (0.15, 95% CI: 0.05, 0.25), 0.22 (95% CI: 0.10, 0.39), respectively, with each 1ln-transformed Tl increase in total samples. Gender-specific analyses revealed that these associations were largely driven by male offspring. In addition, immunohistochemistry revealed that nuclear NF-κB p65 expression increased in placenta tissue. The results of this prospective cohort study provide longitudinal evidence that prenatal Tl exposure induces a placental inflammatory response in the Chinese population. Graphical abstract: Image 1 Highlights: We measured 11 inflammatory cytokine mRNAs expression to observe local immune activation in the placenta. Elevated Tl concentrations were associated with increased placental TNF-α, IL6 and CD68 mRNA expression in longitudinal analysis. Our findings suggest that prenatal Tl exposure may induce the placenta inflammation response via NF-κB activation.