Effect of intramyocardial bone marrow cell injection on left ventricular dyssynchrony and global strain. Issue 2 (15th January 2008)

• Record Type: Journal Article
• Authors: van Ramshorst, J; Atsma, D E; Beeres, S L M A; Mollema, S A; Ajmone Marsan, N; Holman, E R; van der Wall, E E; Schalij, M J; Bax, J J
• Is Part Of: Heart. Volume 95:Issue 2(2009)
• Page Start: 119
• Page End: 124
• Publication Date: 2008-01-15
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2007.129569
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To evaluate the effect of bone marrow cell injection on global strain and left ventricular (LV) dyssynchrony. Methods: In 14 patients with severe postinfarction heart failure, 93 (14)×106 autologous bone marrow cells were percutaneously injected in the infarction border zone. LV ejection fraction (LVEF), LV dyssynchrony and echocardiographic global strain were assessed at baseline and 3 months in patients and in a non-randomised control group of 10 patients with a history of infarction who developed heart failure and were treated medically. Results: No periprocedural complications occurred during bone marrow cell injection. At 3 months mean (SD) LVEF increased from 23 (8)% to 27 (9)% (p = 0.02) and global strain improved from −7.7 (4.7)% to −8.5 (4.9)% (p = 0.04). In patients with ⩾5% improvement in LVEF after bone marrow cell injection, global strain improved from −8.7 (4.6)% to −10.6 (4.5)% (p<0.01). Global strain remained unchanged in patients with <5% improvement in LVEF (−6.6 (4.9)% vs −6.4 (4.5)%, p = NS). The relation between the increase in LVEF and improvement in global strain was significant ( r = 0.84, p<0.01). In patients with ⩾5% improvement in LVEF, LV dyssynchrony decreased from 173 (64) ms to 116 (64) ms (p = 0.01). In patients with <5% improvement in LVEF, LV dyssynchrony remained unchanged (155 (67) ms vs 177 (81) ms, p = NS). The correlation between improvement in LVEF and reduction in LV dyssynchrony was good ( r = −0.77, p<0.01). In the control group, LVEF, global strain and LV dyssynchrony did not improve. Conclusions: Bone marrow cell injection improves LVEF in patients with severe postinfarction heart failure. The improvement in LVEF was related to reduced LV dyssynchrony and increased global strain.