Does β-catenin have a role in pathogenesis of sebaceous cell carcinoma of the eyelid?. Issue 2 (2nd September 2010)

• Record Type: Journal Article
• Authors: Jayaraj, Perumal; Sen, Seema; Kashyap, Seema; Sharma, Anjana; Pushker, Neelam; Bajaj, Mandeep Singh; Ghose, Supriyo; Chosdol, Kunzang
• Is Part Of: British journal of ophthalmology. Volume 95:Issue 2(2011)
• Page Start: 284
• Page End: 287
• Publication Date: 2010-09-02
• Subjects: Eyelid -- sebaceous cell carcinoma -- β-catenin -- Immunohistochemistry -- Wnt/β-catenin signalling pathway -- pathology -- neoplasia; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjo.2009.177204
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Aim: Expression of β-catenin in sebaceous cell carcinoma (SbCC) of the eyelid and its correlation with histopathological features. Method: 48 cases of SbCC were analysed immunohistochemically using monoclonal β-catenin antibody and the results correlated with tumour size, histopathological differentiation, orbital invasion and pagetoid spread. Resuts: Cytoplasmic overexpression of β-catenin was seen in 66% cases of SbCC which correlated positively with tumour size, orbital invasion and pagetoid spread. This correlation was found to be significant in tumour size >2 cm (p=0.242). Nuclear staining was not observed in any of the cases. Conclusion: Cytoplasmic overexpression of β-catenin was observed in the majority of the cases of SbCC of eyelid, and this correlated significantly with tumour size. The authors therefore hypothesise that β-catenin overexpression in SbCC of eyelid may be a result of Wnt/β-catenin pathway dysregulation. However, its role both in the development of sebaceous cell carcinoma of the eyelid as well as its prognosis needs to be explored further.