The quantitative link of lung clearance index to bronchial segments affected by bronchiectasis. Issue 1 (2nd September 2017)

• Record Type: Journal Article
• Authors: Verbanck, Sylvia; King, Gregory G; Zhou, Wenxiao; Miller, Anne; Thamrin, Cindy; Schuermans, Daniel; Ilsen, Bart; Ernst, Caroline W; de Mey, Johan; Vincken, Walter; Vanderhelst, Eef
• Is Part Of: Thorax. Volume 73:Issue 1(2018)
• Page Start: 82
• Page End: 84
• Publication Date: 2017-09-02
• Subjects: Cystic Fibrosis -- Bronchiectasis -- Exhaled Airway Markers -- Respiratory Measurement -- Imaging/CT MRI; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2017-210496
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : In adult patients with cystic fibrosis (CF), the lung clearance index (LCI) derived from the multiple breath washout relates to both acinar and conductive ventilation heterogeneity. The latter component predicts an association between LCI and the number of bronchial segments affected by bronchiectasis. Here, we experimentally demonstrated this association in patients with CF, and also examined an ancillary group of patients with non-CF bronchiectasis. We conclude that lung disease severity in terms of number of bronchial segments results in an associated LCI increase, likely constituting a portion of LCI that cannot be reversed by treatment in patients with CF lung disease.