Self-Assessed Severity as a Determinant of Coronavirus Disease 2019 Symptom Specificity: A Longitudinal Cohort Study. (13th February 2022)

• Record Type: Journal Article
• Authors: Bershteyn, Anna; Dahl, Angela M; Dong, Tracy Q; Deming, Meagan E; Celum, Connie L; Chu, Helen Y; Kottkamp, Angelica C; Greninger, Alexander L; Hoffman, Risa M; Jerome, Keith R; Johnston, Christine M; Kissinger, Patricia J; Landovitz, Raphael J; Laufer, Miriam K; Luk, Alfred; Neuzil, Kathleen M; Paasche-Orlow, Michael K; Pitts, Robert A; Schwartz, Mark D; Stankiewicz Karita, Helen C; Thorpe, Lorna E; Wald, Anna; Zheng, Crystal Y; Wener, Mark H; Barnabas, Ruanne V; Brown, Elizabeth R
• Is Part Of: Clinical infectious diseases. Volume 75:Number 1(2022)
• Page Start: e1180
• Page End: e1183
• Publication Date: 2022-02-13
• Subjects: SARS-CoV-2 -- COVID-19 -- symptoms -- screening -- severity; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciac129
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Coronavirus disease 2019 symptom definitions rarely include symptom severity. We collected daily nasal swab samples and symptom diaries from contacts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) case patients. Requiring ≥1 moderate or severe symptom reduced sensitivity to predict SARS-CoV-2 shedding from 60.0% (95% confidence interval [CI], 52.9%−66.7%) to 31.5% (95% CI, 25.7%− 38.0%) but increased specificity from 77.5% (95% CI, 75.3%−79.5%) to 93.8% (95% CI, 92.7%−94.8%).