Vitamin D in inflammatory bowel disease: From biology to clinical implications. (December 2019)

• Record Type: Journal Article
• Authors: Parizadeh, Seyed Mostafa; Jafarzadeh-Esfehani, Reza; Hassanian, Seyed Mahdi; Mottaghi-Moghaddam, Ali; Ghazaghi, Anahita; Ghandehari, Maryam; Alizade-Noghani, Mohadese; Khazaei, Majid; Ghayour-Mobarhan, Majid; Ferns, Gordon A.; Parizadeh, Seyed Mohammad Reza; Avan, Amir
• Is Part Of: Complementary therapies in medicine. Volume 47(2019)
• Publication Date: 2019-12
• Subjects: Vitamin D -- Inflammatory bowel disease -- Crohn's disease -- Ulcerative colitis -- Supplementation -- Sun exposure; Alternative medicine -- Periodicals; Complementary Therapies -- Periodicals; Médecines parallèles -- Périodiques; Thérapeutique -- Périodiques; Alternative medicine; Electronic journals; Periodicals; 615.5
• DOI: 10.1016/j.ctim.2019.08.023
• Languages: English
• ISSNs: 0965-2299

Abstract

Highlights: Vitamin D deficiency is a major concern in general population as well as in IBD patients. The main focus of most of present clinical studies are on the inflammatory state rather than evaluation clinical outcomes. The exact dose of vitamin D supplementation in IBD patients has not been studied systematically in clinical trials which requires further studies with greater sample size with more emphasizes on every vitamin D sources especially the sun exposure. Abstract: Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory disorder of the gastrointestinal tract consisting two principal categories, ulcerative colitis (UC) and Crohn's disease (CD). The precise etiology of IBD remains unknown. Vitamin D is an important micronutrient that plays a critical biological role in various processes in human tissues. However, the relationship between disruption of the gut microbiota and the development of IBD is unclear. Some studies suggest that IBD is the cause of disrupted gut microbiota while others propose that gut microbiota itself can lead to development of IBD. Regardless of this complexity, it has emerged that vitamin D is an immunoregulatory factor that plays a significant role in the pathogenesis of IBD by affecting the gut microbiome and the inflammatory response. It has been reported that 38.1% of CD patients and 31.6% of UC patients suffer from vitamin D deficiency (VDD). In this review, we aimed to evaluate the association between VDD and IBD, summarizing recent clinical studies examining the effect of low vitamin D and the role of vitamin D supplementation on IBD clinical outcomes.