Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission Dynamics and Immune Responses in a Household of Vaccinated Persons. (17th January 2022)

• Record Type: Journal Article
• Authors: Liu, Jamin; Laurie, Matthew T; Rubio, Luis; Vazquez, Sara E; Sunshine, Sara; Mitchell, Anthea M; Hapte-Selassie, Matthias; Mann, Sabrina A; Pilarowski, Genay; Black, Douglas; Marquez, Carina; Rojas, Susana; Lionakis, Michail S; Petersen, Maya; Whitman, Jeffrey D; Jain, Vivek; Anderson, Mark; Havlir, Diane; DeRisi, Joseph
• Is Part Of: Clinical infectious diseases. Volume 75:Number 1(2022)
• Page Start: e303
• Page End: e306
• Publication Date: 2022-01-17
• Subjects: SARS-CoV-2 -- antibody neutralization -- breakthrough infection -- anti -- interferon autoantibody -- autoimmunity; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciac029
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: While SARS-CoV-2 vaccines prevent severe disease effectively, postvaccination "breakthrough" COVID-19 infections and transmission among vaccinated individuals remain ongoing concerns. We present an in-depth characterization of transmission and immunity among vaccinated individuals in a household, revealing complex dynamics and unappreciated comorbidities, including autoimmunity to type 1 interferon in the presumptive index case.