Reply to Caldwell et al. (3rd December 2021) - Satlin, Michael J; Chen, Liang; Douglass, Claire; Hovan, Michael; Davidson, Emily; Soave, Rosemary; La Spina, Marisa; Gomez-Arteaga, Alexandra; van Besien, Koen; Mayer, Sebastian; Phillips, Adrienne; Hsu, Jing Mei; et al.