Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination. (19th November 2021)

• Record Type: Journal Article
• Authors: Canaday, David H; Oyebanji, Oladayo A; Keresztesy, Debbie; Payne, Michael; Wilk, Dennis; Carias, Lenore; Aung, Htin; St. Denis, Kerri; Lam, Evan C; Rowley, Christopher F; Berry, Sarah D; Cameron, Cheryl M; Cameron, Mark J; Wilson, Brigid M; Balazs, Alejandro B; King, Christopher L; Gravenstein, Stefan
• Is Part Of: Clinical infectious diseases. Volume 75:Number 1(2022)
• Page Start: e884
• Page End: e887
• Publication Date: 2021-11-19
• Subjects: COVID-19 -- vaccine -- long-term care -- antibody; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciab963
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Antibody decline occurred from 2 weeks to 6 months post-BNT162b2 mRNA vaccination in nursing home (NH) residents and healthcare workers. Antispike, receptor-binding domain, and neutralization levels dropped >81% irrespective of prior infection. Notably, 69% of infection-naive NH residents had neutralizing antibodies at or below the assay's limit of detection.