Severe Acute Respiratory Syndrome Coronavirus 2 Adaptive Immunity in Nursing Home Residents Following a Third Dose of the Comirnaty Coronavirus Disease 2019 Vaccine. (21st March 2022)

• Record Type: Journal Article
• Authors: Giménez, Estela; Albert, Eliseo; Zulaica, Joao; Torres, Ignacio; Rusu, Luciana; Moreno, Alicia Rodríguez; Burgos, Javier S; Peiró, Salvador; Salas, Dolores; Vanaclocha, Hermelinda; Limón, Ramón; Alcaraz, María Jesús; Sánchez-Payá, José; Díez-Domingo, Javier; Comas, Iñaki; Gonzáles-Candelas, Fernando; Geller, Ron; Navarro, David
• Is Part Of: Clinical infectious diseases. Volume 75:Number 1(2022)
• Page Start: e865
• Page End: e868
• Publication Date: 2022-03-21
• Subjects: Comirnaty COVID-19 vaccine third dose -- SARS-CoV-2-S antibodies -- SARS-CoV-2-S T cells -- neutralizing antibodies -- nursing home residents; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciac223
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: A third Comirnaty vaccine dose increased severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain antibody levels (median, 93-fold) and neutralizing antibody titers against Wuhan-Hu-1 (median, 57-fold), Beta (me 22-fold), Delta, (median, 43-fold), and Omicron (median, 8-fold) variants, but had less impact on S-reactive T-cell immunity in nursing home residents.