Temporal Dynamics of Anti–Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019. (7th December 2021)

• Record Type: Journal Article
• Authors: Shaw, Elana R; Rosen, Lindsey B; Cheng, Aristine; Dobbs, Kerry; Delmonte, Ottavia M; Ferré, Elise M N; Schmitt, Monica M; Imberti, Luisa; Quaresima, Virginia; Lionakis, Michail S; Notarangelo, Luigi D; Holland, Steven M; Su, Helen C
• Is Part Of: Clinical infectious diseases. Volume 75:Number 1(2022)
• Page Start: e1192
• Page End: e1194
• Publication Date: 2021-12-07
• Subjects: COVID-19 -- IFN-α -- IFN-ω -- autoantibodies -- convalescence; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciab1002
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Binding levels and neutralization activity of anti–type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals before the development of critical viral disease may be challenging.