Identification of prognostic DNA methylation biomarkers in patients with gastrointestinal adenocarcinomas: A systematic review of epigenome-wide studies. (January 2020)

• Record Type: Journal Article
• Authors: d'Errico, Margherita; Alwers, Elizabeth; Zhang, Yan; Edelmann, Dominic; Brenner, Hermann; Hoffmeister, Michael
• Is Part Of: Cancer treatment reviews. Volume 82(2020)
• Publication Date: 2020-01
• Subjects: GI adenocarcinoma -- DNA methylation -- Epigenetics -- Biomarker -- Methylation array; Cancer -- Periodicals; Cancer -- Treatment -- Periodicals; Neoplasms -- therapy -- Periodicals; Cancer -- Périodiques; Cancer -- Traitement -- Périodiques; Cancer -- Treatment; Electronic journals; Periodicals; 616.99406
• DOI: 10.1016/j.ctrv.2019.101933
• Languages: English
• ISSNs: 0305-7372

Abstract

Abstract: This systematic review aims to summarize epigenome-wide studies on aberrant DNA methylation and its association with survival in patients with gastrointestinal adenocarcinoma. The 15 studies identified showed a large variety of methodological approaches for the identification of prognostic epigenetic markers from genome-wide methylation analyses. None of the findings were reported by more than one study in this systematic review. Further validation studies, a better reporting of methods and results are needed, as well as a clearer definition of investigated outcomes. At present, no conclusions can be drawn on the clinical relevance of the reported epigenetic markers.