A solvent-free synthesis of 4-aryl-NH-1, 2, 3-triazoles from ketones utilizing diphenyl phosphorazidate. Issue 9 (19th May 2022)

• Record Type: Journal Article
• Authors: Ishihara, Kotaro; Ishihara, Kazuki; Kato, Yamato; Shibuya, Shota; Shioiri, Takayuki; Matsugi, Masato
• Is Part Of: Synthetic communications. Volume 52:Issue 9/10(2022)
• Page Start: 1326
• Page End: 1335
• Publication Date: 2022-05-19
• Subjects: Ketones -- diphenyl phosphorazidate -- azide -- cycloaddition -- triazoles; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2022.2086466
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: 4-Aryl- NH -1, 2, 3-triazoles were effectively synthesized from benzyl-type ketones utilizing diphenyl phosphorazidate (DPPA) in the presence of 1, 8-diazabicyclo[5.4.0]undec-7-ene in solvent-free conditions. By this approach, various ketones were rapidly converted to the corresponding triazoles. This reaction enables the preparation of NH -1, 2, 3-triazoles without the need for toxic or explosive azidation reagents. Graphical Abstract: UF0001