Adaptive optics ophthalmoscopy: Application to age-related macular degeneration and vascular diseases. (September 2018)

• Record Type: Journal Article
• Authors: Paques, Michel; Meimon, Serge; Rossant, Florence; Rosenbaum, David; Mrejen, Sarah; Sennlaub, Florian; Grieve, Kate
• Is Part Of: Progress in retinal and eye research. Volume 66(2018:Sep.)
• Page Start: 1
• Page End: 16
• Publication Date: 2018-09
• Subjects: Retina -- Periodicals; Retina -- Research -- Methodology -- Periodicals; Eye -- Diseases -- Periodicals; Eye -- Periodicals; Eye Diseases -- Periodicals; Retina -- Periodicals; Rétine -- Périodiques; Rétine -- Recherche -- Méthodologie -- Périodiques; 617.7005
• DOI: 10.1016/j.preteyeres.2018.07.001
• Languages: English
• ISSNs: 1350-9462

Abstract

Abstract: Adaptive optics (AO)-enhanced en face retinal imaging, termed here AO ophthalmoscopy (AOO) has reached a level of robustness which fuels its increasing use in research and clinical centers. Here we will review the contribution of clinical AOO to the understanding and monitoring of 1) age-related macular degeneration and 2) vascular diseases. The main contributions of AOO to the phenotyping of AMD are a better identification of drusen, a better delineation of the limits of atrophy, and the identification of novel features such as punctate hyperreflectivity and mobile melanin-containing clumps. Characterization of progression of atrophy is facilitated by time-lapse imaging. In vessels, AOO enables the observation and measurement of parietal structures and the observation of microscopic pathological features such as small hemorrhages and inflammatory cell accumulations.