Process design methodology for organometallic chemistry in continuous flow systems. Issue 25 (21st June 2018)

• Record Type: Journal Article
• Authors: Hunter, Sarah M.; Susanne, Flavien; Whitten, Robert; Hartwig, Thoralf; Schilling, Mark
• Is Part Of: Tetrahedron. Volume 74:Issue 25(2018)
• Page Start: 3176
• Page End: 3182
• Publication Date: 2018-06-21
• Subjects: Flow chemistry -- Continuous process -- Grignard -- Organometallic; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2018.04.020
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: This publication summarises the methodology applied in the process design and scale up of fast, exothermic reactions using organometallic reagents for synthesis of intermediates in the production of Active Pharmaceutical Ingredient (API). Process understanding was developed by calculation of the kinetic parameters of the desired reactions and subsequent degradation of the reaction products along with calorimetric understanding. A reaction model, developed in silico, was used to specify process parameters to maximise yield and limit product degradation. The designed process operates with pseudo-adiabatic reaction conditions, from ambient temperatures with negligible impurity formation. Graphical abstract: To create your abstract, type over the instructions in the template box below.Fonts or abstract dimensions should not be changed or altered. Image 1