Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury. (March 2020)

• Record Type: Journal Article
• Authors: Hu, Zhongpeng; Du, Ruiping; Xiu, Lei; Bian, Ziyao; Ma, Chaomei; Sato, Naoto; Hattori, Masao; Zhang, Haochi; Liang, Yanchen; Yu, Shuixing; Wang, Xiao
• Is Part Of: Cytokine. Volume 127(2020)
• Publication Date: 2020-03
• Subjects: Ganoderma lucidum -- Triterpenes -- Inflammation -- NF-κB -- MAPK; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2019.154917
• Languages: English
• ISSNs: 1043-4666

Abstract

Graphical abstract: Highlight: Triterpenes of G. lucidum inhibit LPS-induced inflammatory responses. Ganodermanontriol inhibits activation of TLR4/MyD88-mediated NF-κB/MAPK pathways. Ganodermanontriol prevents D-GalN/LPS-induced acute liver injury. Triterpenes may aid in the prevention and treatment of inflammatory diseases. Abstract: Ganoderma lucidum is a popular medicinal mushroom, which has been used as therapeutic for centuries in traditional Chinese medicine. Although G. lucidum showed strong protective effects in prevention or treatment of a variety of inflammatory diseases, the mechanisms underlying the anti-inflammatory properties of triterpenes of G. lucidum remain undefined. In the current study, we demonstrated that ethanol extract and triterpenes of G. lucidum specifically suppressed LPS-mediated inflammatory responses. Notably, ganodermanontriol inhibited the expressions and interactions of TLR4 and MyD88, NF-κB translocation to nucleus and its DNA binding activity, phosphorylation of p38, ErK1/2 and JNK. In vivo, we showed that ganodermanontriol effectively prevented LPS/D-Galactosamine-induced liver injury by reducing TNF-α and IL-6 production, and decrease of ALT/AST release. Collectively, our results revealed a novel role in inhibition of inflammatory diseases for triterpenes that may act through potential inhibition of TLR4-MyD88-mediated NF-κB and MAPK signaling pathways.