An open-source approach to automation in organic synthesis: The flow chemical formation of benzamides using an inline liquid-liquid extraction system and a homemade 3-axis autosampling/product-collection device. Issue 25 (21st June 2018)

• Record Type: Journal Article
• Authors: O'Brien, Matthew; Hall, April; Schrauwen, John; van der Made, Joyce
• Is Part Of: Tetrahedron. Volume 74:Issue 25(2018)
• Page Start: 3152
• Page End: 3157
• Publication Date: 2018-06-21
• Subjects: Low-cost-automation -- Open-source -- Python -- OpenCV -- Raspberry-Pi -- Flow-chemistry -- Amide-formation -- Liquid-liquid extraction; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2018.02.043
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: Several open-source hardware and software technologies (RAMPS, Python, PySerial, OpenCV) were used to control an automated flow chemical synthesis system. The system was used to effect the synthesis of a series of benzamides. An inexpensive Raspberry Pi single board computer provided an electronic interface between the control computer and the RAMPS motor driver boards. Graphical abstract: Image 1