A highly selective and sensitive 1, 8-naphthalimide-based fluorescent sensor for Zn2+ imaging in living cells. Issue 18 (15th September 2019)

• Record Type: Journal Article
• Authors: Liu, Daying; Zhao, Ye; Shi, Jun; Zhu, Hualing; Zhang, Tingting; Qi, Pengpeng; Chen, Jiatong; Yang, Guangming; He, Huarui
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 29:Issue 18(2019)
• Page Start: 2646
• Page End: 2649
• Publication Date: 2019-09-15
• Subjects: Fluorescent sensor -- Naphthalimide -- Iminoacetic acid -- Iminoethoxyacetic acid -- Zinc; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2019.07.046
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Highlights: 1, 8-Naphthalimide-based fluorescent Zn 2+ sensor with a new receptor contained two different arms iminoacetic acid and iminoethoxyacetic acid, was synthesized. It demonstrates high selectivity and sensitivity for sensing Zn 2+ . It was applied successfully to detection of Zn 2+ in aqueous solution and image Zn 2+ in living cells. Abstract: A new 4-amino-1, 8-naphthalimide-based fluorescent sensor, with iminoacetic acid and iminoethoxyacetic acid as receptor, was developed. It was applied successfully to detect Zn 2+ in aqueous solution and living cells. Under physiological pH conditions, it demonstrates high selectivity and sensitivity for sensing Zn 2+ with about 7-fold enhancement in aqueous solution, with a characteristic emission band of 4-amino-1, 8-naphthalimide with a green color centered at 550 nm.