Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population. (6th June 2022)

• Record Type: Journal Article
• Authors: Fujii, Ryosuke; Hishida, Asahi; Nakatochi, Masahiro; Tsuboi, Yoshiki; Suzuki, Koji; Kondo, Takaaki; Ikezaki, Hiroaki; Hara, Megumi; Okada, Rieko; Tamura, Takashi; Shimoshikiryo, Ippei; Suzuki, Sadao; Koyama, Teruhide; Kuriki, Kiyonori; Takashima, Naoyuki; Arisawa, Kokichi; Momozawa, Yukihide; Kubo, Michiaki; Takeuchi, Kenji; Wakai, Kenji
• Is Part Of: Circulation. Volume 15:Number 4(2022)
• Page Start: e003612
• Publication Date: 2022-06-06
• Subjects: blood pressure -- epidemiology -- genetics -- hypertension -- risk factors; Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Genetics -- Periodicals; Cardiovascular Diseases -- genetics; Precision Medicine; Periodical; Fulltext; Internet Resources; Periodicals; Electronic journals; Periodicals; 616.1042
• DOI: 10.1161/CIRCGEN.121.003612
• Languages: English
• ISSNs: 2574-8300

Abstract

Abstract : Background: Although many polygenic risk scores (PRS) for cardiovascular traits have been developed in European populations, it is an urgent task to construct a PRS and to evaluate its ability in non-European populations. We developed a genome-wide PRS for blood pressure in a Japanese population and examined the associations between this PRS and hypertension prevalence. Methods: We performed a cross-sectional study in 11 252 Japanese individuals who participated in the J-MICC (Japan Multi-Institutional Collaborative Cohort) study. Using publicly available GWAS summary statistics from Biobank Japan, we developed the PRS in the target data (n=7876). With >30 000 single nucleotide polymorphisms, we evaluated PRS performance in the test data (n=3376). Hypertension was defined as systolic blood pressure of 130 mm Hg or more, or diastolic blood pressure of 85 mm Hg or more, or taking an antihypertensive drug. Results: Compared with the middle PRS quintile, the prevalence of hypertension at the top PRS quintile was higher independently from traditional risk factors (odds ratio, 1.73 [95% CI, 1.32–2.27]). The difference of mean systolic blood pressure and diastolic blood pressure between the middle and the top PRS quintile was 4.55 (95% CI, 2.26–6.85) and 2.32 (95% CI, 0.86–3.78) mm Hg, respectively. Subgroups reflecting combinations of Japanese PRS and modifiable lifestyles and factors (smoking, alcohol intake, sedentary time, and obesity) were associated with the prevalence of hypertension. A European-derived PRS was not associated with hypertension in our participants. Conclusions: A PRS for blood pressure was significantly associated with hypertension and BP traits in a general Japanese population. Our findings also highlighted the importance of a combination of PRS and risk factors for identifying high-risk subgroups.