Simultaneous Detection of 2 Types of Malignancies in a Pediatric Patient on FDG PET/CT Led to Diagnosis of Li-Fraumeni Syndrome. (12th October 2022)

• Record Type: Journal Article
• Authors: Kan, Ying; Si, Yukun; Wang, Wei; Yang, Jigang
• Is Part Of: Clinical nuclear medicine. Volume 47:Number 10(2022)
• Page Start: 912
• Page End: 913
• Publication Date: 2022-10-12
• Subjects: adrenocortical carcinoma -- FDG PET/CT -- Li-Fraumeni syndrome -- rhabdomyosarcoma; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000004266
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract: A 17-month-old girl underwent FDG PET/CT to evaluate a right adrenal lesion, which showed abnormal 18 F-FDG avidity. In addition, an unexpected lesion with mild 18 F-FDG uptake was noted in the right anterior thoracic wall. Pathology demonstrated adrenocortical carcinoma in the right adrenal and rhabdosarcoma in both the left forearm and right anterior thoracic wall. Gene analysis confirmed the diagnosis of Li-Fraumeni syndrome. The present case emphasized FDG PET/CT value of showing simultaneously multiple lesions in Li-Fraumeni syndrome, especially in the early stage without the gene analysis result.