Tissue attenuation imaging and tissue scatter imaging for quantitative ultrasound evaluation of hepatic steatosis. Issue 33 (19th August 2022)

• Record Type: Journal Article
• Authors: Rónaszéki, Aladár D.; Budai, Bettina K.; Csongrády, Barbara; Stollmayer, Róbert; Hagymási, Krisztina; Werling, Klára; Fodor, Tamás; Folhoffer, Anikó; Kalina, Ildikó; Győri, Gabriella; Maurovich-Horvat, Pál; Kaposi, Pál N.
• Is Part Of: Medicine. Volume 101:Issue 33(2022)
• Page Start: e29708
• Publication Date: 2022-08-19
• Subjects: liver imaging -- nonalcoholic fatty liver disease -- quantitative ultrasound imaging -- ultrasonography; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000029708
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : We aimed to assess the feasibility of ultrasound-based tissue attenuation imaging (TAI) and tissue scatter distribution imaging (TSI) for quantification of liver steatosis in patients with nonalcoholic fatty liver disease (NAFLD). We prospectively enrolled 101 participants with suspected NAFLD. The TAI and TSI measurements of the liver were performed with a Samsung RS85 Prestige ultrasound system. Based on the magnetic resonance imaging proton density fat fraction (MRI-PDFF), patients were divided into ≤5%, 5–10%, and ≥10% of MRI-PDFF groups. We determined the correlation between TAI, TSI, and MRI-PDFF and used multiple linear regression analysis to identify any association with clinical variables. The diagnostic performance of TAI, TSI was determined based on the area under the receiver operating characteristic curve (AUC). The intraclass correlation coefficient (ICC) was calculated to assess interobserver reliability. Both TAI (rs = 0.78, P < .001) and TSI (rs = 0.68, P < .001) showed significant correlation with MRI-PDFF. TAI overperformed TSI in the detection of both ≥5% MRI-PDFF (AUC = 0.89 vs 0.87) and ≥10% (AUC = 0.93 vs 0.86). MRI-PDFF proved to be an independent predictor of TAI (β = 1.03; P < .001), while both MRI-PDFF (β = 50.9; P < .001) and liver stiffness (β = −0.86; P < .001) were independent predictors of TSI. Interobserver analysis showed excellent reproducibility of TAI (ICC = 0.95) and moderate reproducibility of TSI (ICC = 0.73). TAI and TSI could be used successfully to diagnose and estimate the severity of hepatic steatosis in routine clinical practice.