Multi-stimuli controlled release of a transmembrane chloride ion carrier from a sulfonium-linked procarrier. Issue 45 (5th November 2020)

• Record Type: Journal Article
• Authors: Das, Sribash; Biswas, Oindrila; Akhtar, Nasim; Patel, Anjali; Manna, Debasis
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 45(2020)
• Page Start: 9246
• Page End: 9252
• Publication Date: 2020-11-05
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob00938e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : We demonstrated the development of a multi-stimuli activatable anion transport approach to induce regulated transport of Cl − ion across the membranes under specific conditions. Abstract : In recent times, anion transporters have received substantial consideration due to their ability to disrupt the ionic equilibrium across membrane bilayers. While numerous Cl − ion transporters were developed for channelopathies, unfortunately, poor aqueous solubility precluded their bioapplicability. Herein, we demonstrate the development of a multi-stimuli activatable anion transport approach to induce regulated transport of Cl − ions across membranes under specific conditions. The sulfonium-based procarrier was initially inactive, but the transmembrane transport of Cl − ions was activated in the presence of stimuli such as glutathione (GSH), reactive oxygen species (ROS) and light. The release of the hydrophobic anionophore from the aqueous-soluble procarrier under specific conditions leads to the successful transport of Cl − ions. Under physiological conditions, these anion carriers follow an antiport exchange mechanism to transport Cl − ions across lipid bilayers. Such multi-stimuli activatable procarriers have great potential to combat various types of channelopathies, including cancer, cystic fibrosis, kidney stones, myotonia, and others.