Ghrelin and vascular protection. (26th September 2019)

• Record Type: Journal Article
• Authors: Pearson, James T; Shirai, Mikiyasu; Sukumaran, Vijayakumar; Du, Cheng-Kun; Tsuchimochi, Hirotsugu; Sonobe, Takashi; Waddingham, Mark T; Katare, Rajesh; Schwenke, Daryl O
• Is Part Of: Vascular biology. Volume 1:Number 1(2019)
• Page Start: H97
• Page End: H102
• Publication Date: 2019-09-26
• Subjects: ghrelin -- GHS-R1a -- vasodilation -- angiogenesis -- inflammation; Peripheral vascular diseases -- Periodicals; Cardiovascular system -- Periodicals; Blood-vessels -- Diseases -- Periodicals; 573.18
• DOI: 10.1530/VB-19-0024
• Languages: English
• ISSNs: 2516-5658

Abstract

Abstract : Ghrelin is a small peptide with important roles in the regulation of appetite, gut motility, glucose homeostasis as well as cardiovascular protection. This review highlights the role that acyl ghrelin plays in maintaining normal endothelial function by maintaining the balance of vasodilator-vasoconstrictor factors, inhibiting inflammatory cytokine production and immune cell recruitment to sites of vascular injury and by promoting angiogenesis.