Structural remodelling of the heart valves extracellular matrix during embryo development. (14th August 2020)

• Record Type: Journal Article
• Authors: Falla Zuñiga, Luis Felipe; Muñoz Cerón, Yhoiss Smiht; Salazar, Liliana
• Is Part Of: Anatomia, histologia, embryologia. Volume 50:Number 1(2021)
• Page Start: 206
• Page End: 211
• Publication Date: 2020-08-14
• Subjects: collagen type I -- collagen type III -- extracellular matrix -- heart valves -- mice; Anatomy, Comparative -- Periodicals; Veterinary anatomy -- Periodicals; Veterinary histology -- Periodicals; Veterinary embryology -- Periodicals; 636.089
• DOI: 10.1111/ahe.12603
• Languages: English
• ISSNs: 0340-2096

Abstract

Abstract: Alterations in heart valve development represent more than 20% of congenital cardiovascular malformations. Most of the functional properties of heart valves depend on extracellular matrix. Despite its relevance, little is known about fibrillar components on developing stages. Our objective is to define histological changes on valves fibrillar components in late embryonic development of Mus musculus . We found type III collagen as the predominant fibre type in the ECM in prenatal stages followed by a switch to a type I predominance for postnatal ages. The change in fibrillar components is necessary to support the normal mechanical function of adult heart valves.