Cover Feature: Simple Synthesis of a Heterocyclophane Exhibiting Anti‐c‐Met Activity by Acting as a Hatch Blocking Access to the Active Site (Chem. Eur. J. 5/2021). Issue 5 (14th January 2021)

• Record Type: Journal Article
• Authors: Takimoto, Tatsuya; Sasaki, Hideaki; Tsue, Hirohito; Takahashi, Hiroki; MacKerell, Alexander D.; Nakamura, Ayumi; Nakano, Katsuya; Okazaki, Eori; Betsuyaku, Tatsuki; Tachibana, Ryosuke; Hioki, Kazuhito; Yoluk, Ozge; Jo, Sunhwan
• Is Part Of: Chemistry. Volume 27:Issue 5(2021)
• Page Start: 1479
• Page End: 1479
• Publication Date: 2021-01-14
• Subjects: computational chemistry -- cyclophanes -- drug design -- inhibitors -- synthetic design; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202004973
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Rapidly synthesis of suitable drug candidates using both a simple cyclophane synthesis and the fragmap method of SILCS in computational chemistry is reported in this work. The cover image depicts cyclophane synthesis using a waffle‐making device so that it is easy to imagine that cyclophane derivatives can be quickly synthesized by heat. More information can be found in the Full Paper by H. Sasaki et al. on page 1648 .