Poloxamer 407‐based Floating Hydrogels for Intravesical Instillation: Statistical Optimization Using Central Composite Design, Gel Erosion, and Drug Release. (4th December 2020)

• Record Type: Journal Article
• Authors: Yang, Hee Mang; Yoon, Ho Yup; Kim, Chang Hyun; Goo, Yoon Tae; Choi, Ik Joon; Park, Sang‐Gue; Chang, In Ho; Choi, Young Wook
• Is Part Of: Bulletin of the Korean Chemical Society. Volume 42:Number 1(2021)
• Page Start: 72
• Page End: 79
• Publication Date: 2020-12-04
• Subjects: Poloxamer 407 -- Floating hydrogel -- Gemcitabine -- Intravesical instillation -- Central composite design; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/bkcs.12160
• Languages: English
• ISSNs: 0253-2964

Abstract

Abstract : Poloxamer 407 (POL) is widely used as a thermosensitive hydrogel for intravesical instillation. When POL hydrogel is instilled in the bladder, several problems, including urinary tract obstruction, are observed. To overcome this problem, a POL‐based floating hydrogel (PFH) system was developed. Sodium bicarbonate (BC) was used as a floating agent. PFH was optimized using a central composite design with two independent variables (X1 [POL concentration, 42.43%] and X2 [BC concentration, 5.23%]) and three response factors (Y1 [floating time, 240.33 s], Y2 [duration time, 270 min], and Y3 [viscosity, 110.39 Pa . s]). In gel erosion and drug‐release studies in vitro, the remaining PFH fraction decreased exponentially with time, while gemcitabine release was biphasic and surface erosion‐controlled. A plot of drug release versus gel erosion showed good linearity. Visual observation for floating, gel duration, and dye release supported the time‐course behaviors of the PFH, indicating its usefulness in intravesical instillation. Abstract : To treat for bladder cancer, the composition of optimized hydrogel is poloxamer 43.43% and sodium bicarbonate 5.23%. That hydrogel shows good drug release and gel erosion properties, thereby, the optimized hydrogel is an option of intravesical instillation