Nanoplatforms for mRNA Therapeutics. Issue 1 (21st July 2020)

• Record Type: Journal Article
• Authors: Meng, Chaoyang; Chen, Zhe; Li, Gang; Welte, Thomas; Shen, Haifa
• Is Part Of: Advanced therapeutics. Volume 4:Issue 1(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-21
• Subjects: lipoplexes -- lipopolyplexes -- mRNA delivery -- nanoplatforms -- polyplexes; Therapeutics -- Periodicals; Pharmaceutical technology -- Periodicals; Pharmacogenetics -- Periodicals; 615.5
• DOI: 10.1002/adtp.202000099
• Languages: English
• ISSNs: 2366-3987

Abstract

Abstract: mRNA‐based therapeutics are a unique class of drugs for treatment of human diseases. Since in vitro transcribed mRNA molecules have relatively low stability and their surface charge prevents them from direct cell entry, they need to be packaged into specially designed delivery platforms to exert their activities. Multiple nanotechnology‐based delivery platforms have been developed for mRNA delivery, such as polymer‐based polyplex, lipid‐based lipoplex, and lipid‐coated polymer‐based lipopolyplex. In this review, an overview of the nanoplatforms for mRNA delivery is provided. A number of applications in biotechnology including cell reprogramming and gene editing are also described. In addition, their clinical translational potential for protein replacement therapy and for infectious disease and cancer treatment is introduced. Abstract : mRNA‐based therapeutics are a unique class of drugs for human disease treatment. Multiple types of delivery platforms have been developed to deliver mRNA molecules into target cells, to promote mRNA translation, and to ensure drug efficacy. A number of mRNA‐based therapies are at different stages of clinical evaluation for treatment of cancer and infectious diseases, including the globally rampant COVID‐19.