Black titanium dioxide@manganese dioxide for glutathione-responsive MR imaging and enhanced photothermal therapy. Issue 2 (11th December 2020)

• Record Type: Journal Article
• Authors: Gao, Yang; Yin, Zhibin; Ji, Qian; Jiang, Jiabing; Tao, Zhengzheng; Zhao, Xiaolong; Sun, Sijia; Wu, Aiguo; Zeng, Leyong
• Is Part Of: Journal of materials chemistry. Volume 9:Issue 2(2020)
• Page Start: 314
• Page End: 321
• Publication Date: 2020-12-11
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d0tb02514c
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Manganese dioxide (MnO2 ) coated black commercial P25 titanium dioxide (b-P25) for glutathione (GSH)-responsive magnetic resonance (MR) imaging and enhanced photothermal therapy (PTT). Abstract : Multifunctional nanoprobes with tumor microenvironment response are playing important roles in highly efficient theranostics of cancers. Herein, a kind of theranostic nanoprobe was synthesized by coating manganese dioxide (MnO2 ) on the surface of black commercial P25 titanium dioxide (b-P25). The resultant nanoprobe (b-P25@MnO2 ) possessed glutathione (GSH)-responsive magnetic resonance (MR) imaging and enhanced photothermal therapy (PTT). In tumor microenvironments, the excessive GSH was consumed by reacting with MnO2 to generate Mn 2+ for GSH-responsive MR imaging, in which the longitudinal relaxation rate of b-P25@MnO2 was up to 30.44 mM −1 s −1, showing excellent cellular and intratumoral MR imaging. Moreover, the prepared b-P25@MnO2 exhibited stable and strong photothermal conversion capability with a high photothermal conversion efficiency of 30.67%, by which the 4T1 tumors disappeared completely, indicating safe and highly efficient PTT performance. The current work developed GSH-responsive b-P25@MnO2 nanoprobes, demonstrated for MR imaging and enhanced PTT in cancers.