The impact of embryo binucleation depends upon its origin. Issue 1 (July 2020)

• Record Type: Journal Article
• Authors: Gomes Paim, Lia Mara; FitzHarris, Greg
• Is Part Of: Reproduction. Volume 160:Issue 1(2020)
• Page Start: V1
• Page End: V4
• Publication Date: 2020-07
• Subjects: Reproduction -- Periodicals; Reproduction -- Molecular aspects -- Periodicals; Reproduction -- Immunological aspects -- Periodicals; Reproduction -- Endocrine aspects -- Periodicals; Fertility -- Periodicals; Human reproduction -- Periodicals; 571.805
• DOI: 10.1530/REP-20-0188
• Languages: English
• ISSNs: 1470-1626

Abstract

Abstract : Summary: Preimplantation embryos frequently contain binucleated cells, but reports differ as to whether binucleation affects development and whether such embryos should be used clinically. In this Point Of View article, we propose a possible explanation for this disparity: binucleation can arise by distinct routes, one that produces healthy blastomeres and one that directly threatens embryo viability.