Case of ovarian steroid cell tumor diagnosed after presenting acute heart failure. Issue 7 (27th May 2020)

• Record Type: Journal Article
• Authors: Matsuda, Shigeru; Yamaguchi, Yuu; Kaseki, Hanako; Watanabe, Kenichiro; Ono, Shuichi; Yamamoto, Akihito; Ichikawa, Masao; Akira, Shigeo; Takeshita, Toshiyuki
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 46:Issue 7(2020)
• Page Start: 1211
• Page End: 1215
• Publication Date: 2020-05-27
• Subjects: heart failure -- hypertestosteronemia -- secondary menorrhea -- steroid cell tumor -- virilization sign; Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.14339
• Languages: English
• ISSNs: 1341-8076

Abstract

Abstract: We report a rare case of an ovarian steroid cell tumor with a diagnosis prompted by heart failure symptoms. A 28‐year‐old Japanese nulligravida/nullipara with a chief complaint of respiratory discomfort during physical exertion and exhibiting heart failure symptoms was referred to our hospital. She also had signs of virilization, including secondary menorrhea since the age of 20, hirsutism and balding. Cushing's syndrome was suspected, and further examinations showed hypertestosteronemia and right ovarian tumor. Symptomatic treatment for heart failure with diuretics and antihypertensives was followed by abdominal right adnexectomy performed due to the androgen‐producing ovarian tumor. The tumor was solid and larger than a fist, and confirmed as a steroid cell tumor through postoperative histopathology. Serum total testosterone levels normalized at day 3 postoperatively, and menstruation resumed 2 months later. Our case was diagnosed due to heart failure symptoms, and its treatment resulted in improvement in virilization signs.