Baseline factors associated with early and late death in intracerebral haemorrhage survivors. (28th April 2020)

• Record Type: Journal Article
• Authors: Banerjee, G.; Ambler, G.; Wilson, D.; Hostettler, I. C.; Shakeshaft, C.; Lunawat, S.; Cohen, H.; Yousry, T.; Al‐Shahi Salman, R.; Lip, G. Y. H.; Houlden, H.; Muir, K. W.; Brown, M. M.; Jäger, H. R.; Werring, D. J.
• Other Names: Shaw Louise investigator.; Harkness Kirsty investigator.; Sword Jane investigator.; Mohd Nor Azlisham investigator.; Sharma Pankaj investigator.; Kelly Deborah investigator.; Harrington Frances investigator.; Randall Marc investigator.; Smith Matthew investigator.; Mahawish Karim investigator.; Elmarim Abduelbaset investigator.; Esisi Bernard investigator.; Cullen Claire investigator.; Nallasivam Arumug investigator.; Price Christopher investigator.; Barry Adrian investigator.; Roffe Christine investigator.; Coyle John investigator.; Hassan Ahamad investigator.; Lovelock Caroline investigator.; Birns Jonathan investigator.; Cohen David investigator.; Sekaran L. investigator.; Parry‐Jones Adrian investigator.; Parry Anthea investigator.; Hargroves David investigator.; Proschel Harald investigator.; Datta Prabel investigator.; Darawil Khaled investigator.; Manoj Aravindakshan investigator.; Burn Mathew investigator.; Patterson Chris investigator.; Giallombardo Elio investigator.; Smyth Nigel investigator.; Mansoor Syed investigator.; Anwar Ijaz investigator.; Marsh Rachel investigator.; Ispoglou Sissi investigator.; Chadha Dinesh investigator.; Prabhakaran Mathuri investigator.; Meenakishundaram Sanjeevikumar investigator.; O'Connell Janice investigator.; Scott Jon investigator.; Krishnamurthy Vinodh investigator.; Aghoram Prasanna investigator.; McCormick Michael investigator.; O'Mahony Paul investigator.; Cooper Martin investigator.; Choy Lillian investigator.; Wilkinson Peter investigator.; Leach Simon investigator.; Caine Sarah investigator.; Burger Ilse investigator.; Gunathilagan Gunaratam investigator.; Guyler Paul investigator.; Emsley Hedley investigator.; Davis Michelle investigator.; Manawadu Dulka investigator.; Pasco Kath investigator.; Mamun Maam investigator.; Luder Robert investigator.; Sajid Mahmud investigator.; Anwar Ijaz investigator.; Okwera James investigator.; Staals Julie investigator.; Warburton Elizabeth investigator.; Saastamoinen Kari investigator.; England Timothy investigator.; Putterill Janet investigator.; Flossman Enrico investigator.; Power Michael investigator.; Dani Krishna investigator.; Mangion David investigator.; Suman Appu investigator.; Corrigan John investigator.; Lawrence Enas investigator.; Vahidassr Djamil investigator.;
• Is Part Of: European journal of neurology. Volume 27:Number 7(2020)
• Page Start: 1257
• Page End: 1263
• Publication Date: 2020-04-28
• Subjects: intracerebral haemorrhage -- mortality -- prognosis; Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.14238
• Languages: English
• ISSNs: 1351-5101

Abstract

Abstract : Background and purpose: The aim of this study was to determine whether early and late death are associated with different baseline factors in intracerebral haemorrhage (ICH) survivors. Methods: This was a secondary analysis of the multicentre prospective observational CROMIS‐2 ICH study. Death was defined as 'early' if occurring within 6 months of study entry and 'late' if occurring after this time point. Results: In our cohort ( n = 1094), there were 306 deaths (per 100 patient‐years: absolute event rate, 11.7; 95% confidence intervals, 10.5–13.1); 156 were 'early' and 150 'late'. In multivariable analyses, early death was independently associated with age [per year increase; hazard ratio (HR), 1.05, P = 0.003], history of hypertension (HR, 1.89, P = 0.038), pre‐event modified Rankin scale score (per point increase; HR, 1.41, P < 0.0001), admission National Institutes of Health Stroke Scale score (per point increase; HR, 1.11, P < 0.0001) and haemorrhage volume >60 mL (HR, 4.08, P < 0.0001). Late death showed independent associations with age (per year increase; HR, 1.04, P = 0.003), pre‐event modified Rankin scale score (per point increase; HR, 1.42, P = 0.001), prior anticoagulant use (HR, 2.13, P = 0.028) and the presence of intraventricular extension (HR, 1.73, P = 0.033) in multivariable analyses. In further analyses where time was treated as continuous (rather than dichotomized), the HR of previous cerebral ischaemic events increased with time, whereas HRs for Glasgow Coma Scale score, National Institutes of Health Stroke Scale score and ICH volume decreased over time. Conclusions: We provide new evidence that not all baseline factors associated with early mortality after ICH are associated with mortality after 6 months and that the effects of baseline variables change over time. Our findings could help design better prognostic scores for later death after ICH.