Diffusion-derived parameters in lesions, peri-lesion and normal-appearing white matter in multiple sclerosis using tensor, kurtosis and fixel-based analysis. Issue 11 (November 2022)

• Record Type: Journal Article
• Authors: van der Weijden, Chris WJ; van der Hoorn, Anouk; Potze, Jan Hendrik; Renken, Remco J; Borra, Ronald JH; Dierckx, Rudi AJO; Gutmann, Ingomar W; Ouaalam, Hakim; Karimi, Davood; Gholipour, Ali; Warfield, Simon K; de Vries, Erik FJ; Meilof, Jan F
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 42:Issue 11(2022)
• Page Start: 2095
• Page End: 2106
• Publication Date: 2022-11
• Subjects: Axonal integrity -- diffusion kurtosis imaging -- diffusion tensor imaging -- fixel-based analysis -- multiple sclerosis; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1177/0271678X221107953
• Languages: English
• ISSNs: 0271-678X

Abstract

Abstract: Neuronal damage is the primary cause of long-term disability of multiple sclerosis (MS) patients. Assessment of axonal integrity from diffusion MRI parameters might enable better disease characterisation. 16 diffusion derived measurements from diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and fixel-based analysis (FBA) in lesions, peri-lesion and normal appearing white matter were investigated. Diffusion MRI scans of 11 MS patients were processed to generate DTI, DKI, and FBA images. Fractional anisotropy (FA) and fibre density (FD) were used to assess axonal integrity across brain regions. Subsequently, 359 lesions were identified, and lesion and peri-lesion segmentation was performed using structural T1 w, T2 w, T2 w-FLAIR, and T1 w post-contrast MRI. The segmentations were then used to extract 16 diffusion MRI parameters from lesion, peri-lesion, and contralateral normal appearing white matter (NAWM). The measurements for axonal integrity, DTI-FA, DKI-FA, FBA-FD, produced similar results. All diffusion MRI parameters were affected in lesions as compared to NAWM (p < 0.001), confirming loss of axonal integrity in lesions. In peri-lesions, most parameters, except FBA-FD, were also significantly different from NAWM, although the effect size was smaller than in lesions. The reduction in axonal integrity in peri-lesions, despite unaffected fibre density estimates, suggests an effect of Wallerian degeneration.